Search on: I-KAPPA B PROTEINS 
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Descriptor English:   I-kappa B Proteins 
Descriptor Spanish:   Proteínas I-kappa B 
Descriptor Portuguese:   Proteínas I-kappa B 
Tree Number:   D12.644.360.378
D12.776.260.420
D12.776.476.381
D12.776.930.326
Definition English:   A family of inhibitory proteins which bind to the REL PROTO-ONCOGENE PROTEINS and modulate their activity. In the CYTOPLASM, I-kappa B proteins bind to the transcription factor NF-KAPPA B. Cell stimulation causes its dissociation and translocation of active NF-kappa B to the nucleus. 
See Related English:   I-kappa B Kinase
NF-kappa B
Proto-Oncogene Proteins c-rel
 
History Note English:   2006(2000) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DU diagnostic use
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   34471 
Unique Identifier:   D020672 

Occurrence in VHL:
 

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